Adrenergic alpha-2 Receptor Antagonists
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Adrenergic alpha-2 Receptor Antagonists
Latest published update: 30 Jul 2026Exam Points3
View all →Alpha-2 antagonists: classification
Yohimbine is a relatively selective alpha-2 antagonist.
Alpha-2 antagonists: mechanism
Presynaptic alpha-2 blockade removes negative feedback on norepinephrine release, increasing sympathetic and central noradrenergic activity.
Alpha-2 antagonists: adverse effects and precautions
Anxiety, agitation, hypertension, tachycardia, tremor and insomnia can occur with yohimbine.
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