Angiotensin-Converting Enzyme Inhibitors
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AMD:CLASS:00926
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ACE inhibitors suppress conversion of angiotensin I to angiotensin II and reduce degradation of bradykinin.
Reduced angiotensin II lowers vasoconstriction and aldosterone signalling. Efferent arteriolar dilation can reduce intraglomerular pressure.
Cough, hyperkalaemia, hypotension, a rise in creatinine and rare angioedema are class-defining concerns.
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